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Formula: C17H35N4O14P3
ATC0065 bounds with high affinity to the MCH-R1 with IC50 value of 16 nMand showed good metabolic stability in liver microsomes isolated from human and rat 1
1 nM in human and monkey blood
and the p70S6K target S6RP are also observed in PTEN-deficient MES-SA human uterine tumor xenografts after treatment with 40 and 50 mg/kg p
Q-VD(OMe)-OPh 5EF hydrochloride Formula: C17H35N4O14P3Q VD OPh (quinolyl valyl O methylaspartyl [ 2,6 difluorophenoxy] methyl ketone) is a broad spectrum caspase inhibitor, provides a cost effective, non toxic, and highly specific means of apoptotic inhibition and provides new insight into the design of new inhibitors. It is significantly more effective in preventing apoptosis than the widely used inhibitors, ZVAD fmk and Boc D fmk. Q VD OPh is also equally effective in preventing apoptosis mediated by